Haematology
Smoldering Myeloma Risk with the Free Light-Chain Ratio calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–100 %
At least 10% scores 1. If both this percentage is under 10 and the M protein is under 3 g/dL, the model has no row.
Allowed range: 0–10 g/dL
At least 3 g/dL scores 1. A value of exactly 3 does.
Allowed range: 0–100000 κ/λ
Enter the kappa-to-lambda ratio. Below 0.125 or above 8 scores 1. From 0.125 through 8, including both ends, does not.
Result
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Clinical inputs
- Bone marrow plasma cells (%)Accepted range: 0 to 100
- Serum M protein (g/dL)Accepted range: 0 to 10
- Serum free light-chain ratio (κ/λ)Accepted range: 0 to 100000
Primary source
Dispenzieri A et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood. DOI: 10.1182/blood-2007-08-108357. PMID: 17942755. One point each for bone marrow plasma cells ≥10%, serum M protein ≥3 g/dL, and a serum κ/λ free light-chain ratio <0.125 or >8. One point has a median time to progression of 10 years and a 5-year progression rate of 25%. Two points: 5.1 years and 51%. Three points: 1.9 years and 76%. A result with neither marrow ≥10% nor M protein ≥3 g/dL is outside the smoldering cohort and is not scored. (2008)
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