Haematology
Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 18–110 years
Age greater than 60 years scores 1 point. Age 60 does not.
Allowed range: 4–20 g/dL
Hemoglobin under 10 g/dL scores 1 point. A value of 10 does not.
Allowed range: 1000–2000000 /µL
Platelets under 100×10^9/L score 1 point. A count of 100 does not.
Result
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Clinical inputs
- Age (years)Accepted range: 18 to 110
- Hemoglobin (g/dL)Accepted range: 4 to 20
- Platelet count (×10^9/L)Accepted range: 1 to 2000
- SRSF2, ASXL1, or RUNX1 mutations
Primary source
Jawhar M et al. MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis. J Clin Oncol. DOI: 10.1200/JCO.19.00640. PMID: 31509472. One point each for age >60 years, hemoglobin <10 g/dL, platelets <100×10^9/L, and one mutation among SRSF2, ASXL1, and RUNX1. Two points for two or more of those genes. One gene and two or more genes are separate categories, so the total runs from 0 to 5. Low risk is 0–1 (median overall survival not reached), intermediate risk is 2 (3.9 years in the training set), and high risk is 3–5 (1.9 years). (2019)
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