Haematology · Oncology
MYSEC-PM calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–120 years
Allowed range: 3–20 g/dL
Below 11 g/dL adds 2 points. 11 g/dL does not.
Allowed range: 0–2000000 /µL
Below 150×10^9/L adds 1 point. 150×10^9/L does not.
Allowed range: 0–100 %
At least 3% adds 2 points. 2.9% does not.
Result
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Clinical inputs
- Age (years)Accepted range: 0 to 120
- Hemoglobin (g/dL)Accepted range: 3 to 20
- Platelet count (×10^9/L)Accepted range: 0 to 2000
- Circulating blasts (%)Accepted range: 0 to 100
- CALR mutation absent
- Constitutional symptoms
Primary source
Passamonti F et al. A clinical-molecular prognostic model to predict survival in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis. Leukemia. DOI: 10.1038/leu.2017.169. PMID: 28561069. Table 3 assigns 0.15 points per year of age, 2 for hemoglobin below 11 g/dL, 1 for platelets below 150×10^9/L, 2 for circulating blasts of at least 3%, 2 for a CALR-unmutated genotype, and 1 for constitutional symptoms. Low risk is a sum below 11 (median survival not reached), intermediate-1 is 11 up to but not including 14 (median 9.3 years, 95% CI 8.1 to not reached), intermediate-2 is 14 up to but not including 16 (median 4.4 years, 95% CI 3.2–7.9), and high risk is 16 or more (median 2 years, 95% CI 1.7–3.9). The figure legend walks hemoglobin 10 g/dL and blasts 6% (non-age sum 4) at age 40 into low risk and at age 70 into intermediate-2. A sum that sits below a boundary but would round to that boundary is shown one tenth lower so the category keeps the paper's strict cutoffs. (2017)
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