Haematology · Oncology

IMWG 2014 Multiple Myeloma Criteria calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Clonal bone-marrow plasma cells ≥10%, or a biopsy-proven plasmacytomaHypercalcemia: serum calcium >1 mg/dL above the upper limit or >11 mg/dLRenal insufficiency: creatinine >2 mg/dL or creatinine clearance <40 mL/minAnemia: hemoglobin <10 g/dL or >2 g/dL below the lower limit of normalOne or more osteolytic lesions on skeletal radiography, CT, or PET-CTBone-marrow clonal plasma cells ≥60%Involved/uninvolved serum free light-chain ratio ≥100, with the involved chain ≥10 mg/dLMore than one focal lesion at least 5 mm in size on MRI

Result

Anyone can run this calculator. Sign in to save, favourite, or send the result.

Myeloma-defining criteria not met

Band: Myeloma-defining criteria not met

Interpretation. Myeloma-defining criteria not met

Suggested management. IMWG 2014 myeloma requires clonal bone-marrow plasma cells of at least 10% or a biopsy-proven plasmacytoma, plus one myeloma-defining event (a CRAB feature or a biomarker).

IMWG 2014 Multiple Myeloma Criteria: 0 — Myeloma-defining criteria not met. Interpretation: Myeloma-defining criteria not met What to do: IMWG 2014 myeloma requires clonal bone-marrow plasma cells of at least 10% or a biopsy-proven plasmacytoma, plus one myeloma-defining event (a CRAB feature or a biomarker). Inputs: Clonal bone-marrow plasma cells ≥10%, or a biopsy-proven plasmacytoma: false; Hypercalcemia: serum calcium >1 mg/dL above the upper limit or >11 mg/dL: false; Renal insufficiency: creatinine >2 mg/dL or creatinine clearance <40 mL/min: false; Anemia: hemoglobin <10 g/dL or >2 g/dL below the lower limit of normal: false; One or more osteolytic lesions on skeletal radiography, CT, or PET-CT: false; Bone-marrow clonal plasma cells ≥60%: false; Involved/uninvolved serum free light-chain ratio ≥100, with the involved chain ≥10 mg/dL: false; More than one focal lesion at least 5 mm in size on MRI: false Source: Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. PMID: 25439696. Myeloma requires clonal bone-marrow plasma cells ≥10% or a biopsy-proven plasmacytoma, plus a myeloma-defining event: CRAB (calcium >11 mg/dL or 1 mg/dL above the upper limit, creatinine >2 mg/dL or clearance <40 mL/min, hemoglobin <10 g/dL or 2 g/dL below the lower limit, or a lytic or osteoporotic lesion) or a biomarker (marrow ≥60%, involved/uninvolved free light-chain ratio ≥100 with the involved chain ≥10 mg/dL, or more than one focal MRI lesion). (2014)

Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. PMID: 25439696. Myeloma requires clonal bone-marrow plasma cells ≥10% or a biopsy-proven plasmacytoma, plus a myeloma-defining event: CRAB (calcium >11 mg/dL or 1 mg/dL above the upper limit, creatinine >2 mg/dL or clearance <40 mL/min, hemoglobin <10 g/dL or 2 g/dL below the lower limit, or a lytic or osteoporotic lesion) or a biomarker (marrow ≥60%, involved/uninvolved free light-chain ratio ≥100 with the involved chain ≥10 mg/dL, or more than one focal MRI lesion). (2014)

Ruqelo is AI and can make mistakes. Check important information.

Clinical inputs

Clonal bone-marrow plasma cells ≥10%, or a biopsy-proven plasmacytoma
Hypercalcemia: serum calcium >1 mg/dL above the upper limit or >11 mg/dL
Renal insufficiency: creatinine >2 mg/dL or creatinine clearance <40 mL/min
Anemia: hemoglobin <10 g/dL or >2 g/dL below the lower limit of normal
One or more osteolytic lesions on skeletal radiography, CT, or PET-CT
Bone-marrow clonal plasma cells ≥60%
Involved/uninvolved serum free light-chain ratio ≥100, with the involved chain ≥10 mg/dL
More than one focal lesion at least 5 mm in size on MRI

Primary source

Rajkumar SV et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. PMID: 25439696. Myeloma requires clonal bone-marrow plasma cells ≥10% or a biopsy-proven plasmacytoma, plus a myeloma-defining event: CRAB (calcium >11 mg/dL or 1 mg/dL above the upper limit, creatinine >2 mg/dL or clearance <40 mL/min, hemoglobin <10 g/dL or 2 g/dL below the lower limit, or a lytic or osteoporotic lesion) or a biomarker (marrow ≥60%, involved/uninvolved free light-chain ratio ≥100 with the involved chain ≥10 mg/dL, or more than one focal MRI lesion). (2014)

View source