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Haematology

WPSS for Myelodysplastic Syndrome calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

WHO category

RA, RARS, or MDS with isolated del(5q) and marrow blasts under 5% score 0. RCMD or RCMD-RS scores 1. RAEB-1 scores 2. RAEB-2 scores 3.

Karyotype class

Good is normal, −Y, del(5q), or del(20q) and scores 0. Other abnormalities score 1. Poor is a complex karyotype with 3 or more abnormalities, or a chromosome 7 anomaly, and scores 2.

Red-cell transfusion requirement

Regular means at least one red-cell transfusion every 8 weeks over a period of 4 months, and scores 1.

Result

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Clinical inputs

  • WHO category
  • Karyotype class
  • Red-cell transfusion requirement

Primary source

Malcovati L et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol. DOI: 10.1200/JCO.2006.08.5696. PMID: 17687155. WHO category: RA, RARS, or isolated del(5q) with marrow blasts <5% = 0; RCMD or RCMD-RS = 1; RAEB-1 = 2; RAEB-2 = 3. Karyotype: good (normal, −Y, del(5q), del(20q)) = 0; intermediate = 1; poor (complex with ≥3 abnormalities, or chromosome 7 anomalies) = 2. Regular transfusion is at least one RBC transfusion every 8 weeks over 4 months and scores 1. Very low is 0 (learning median survival 103 months), low is 1 (72 months), intermediate is 2 (40 months), high is 3–4 (21 months), and very high is 5–6 (12 months). (2007)

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