Nephrology · ICU and Critical Care

Kinetic eGFR calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Steady-state creatinine

mg/dL

Allowed range: 0.1–30 mg/dL

Any creatinine that has a matching clearance. Their product stands in for creatinine production and can be reused through one acute episode.

Clearance matching that creatinine

mL/min

Allowed range: 1–250 mL/min

The paper's worked rise uses 1.10 mg/dL with a clearance of 91 mL/min.

Earlier creatinine

mg/dL

Allowed range: 0.1–30 mg/dL

Later creatinine

mg/dL

Allowed range: 0.1–30 mg/dL

Hours between the two creatinines

hours

Allowed range: 0.1–168 hours

Maximum creatinine rise if anuric

mg/dL/day

Allowed range: 0.1–10 mg/dL/day

Per day. The worked example uses 1.5 mg/dL per day. The paper also describes a customary range of 1.0 to 1.5 and observed intensive-care values of 1.3 to 2.0.

Result

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Primary source

Chen S. Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol. DOI: 10.1681/ASN.2012070653. PMID: 23704286. KeGFR = (steady-state creatinine × its clearance / mean of the two creatinines) × (1 − 24 × change in creatinine / (hours × maximum daily rise)). Change is the later creatinine minus the earlier one. The paper's step-decrement example uses 1.10 mg/dL with clearance 91 mL/min, a rise from 1.10 to 2.29 mg/dL in 23 hours, and a maximum rise of 1.5 mg/dL per day, and describes the result as near 10 mL/min. (2013)

Scope: A changing plasma creatinine. The steady-state pair can be any creatinine and the clearance that belongs to it. Creatinine units must match. When the rise is faster than the stated daily maximum, the result is 0.

Last reviewed 2026-10-16

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Chen S. Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol. DOI: 10.1681/ASN.2012070653. PMID: 23704286. KeGFR = (steady-state creatinine × its clearance / mean of the two creatinines) × (1 − 24 × change in creatinine / (hours × maximum daily rise)). Change is the later creatinine minus the earlier one. The paper's step-decrement example uses 1.10 mg/dL with clearance 91 mL/min, a rise from 1.10 to 2.29 mg/dL in 23 hours, and a maximum rise of 1.5 mg/dL per day, and describes the result as near 10 mL/min. (2013)

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Clinical inputs

Steady-state creatinine (mg/dL)Accepted range: 0.1 to 30
Clearance matching that creatinine (mL/min)Accepted range: 1 to 250
Earlier creatinine (mg/dL)Accepted range: 0.1 to 30
Later creatinine (mg/dL)Accepted range: 0.1 to 30
Hours between the two creatininesAccepted range: 0.1 to 168
Maximum creatinine rise if anuric (mg/dL/day)Accepted range: 0.1 to 10

Primary source

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