Nephrology
Kidney Failure Risk Equation, 4 variables calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 18–100 years
Allowed range: 10–59 mL/min/1.73 m²
Enter eGFR in mL/min/1.73 m². The 2011 cohorts used values from 10 through 59.
Allowed range: 1–10000 mg/g
The equation uses the natural log of ACR in mg/g. A value in mg/mmol is multiplied by 8.84.
Result
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Clinical inputs
- Age (years)Accepted range: 18 to 100
- Sex
- Estimated GFR (mL/min/1.73 m²)Accepted range: 10 to 59
- Urine albumin-to-creatinine ratio (mg/g)Accepted range: 1 to 10000
Primary source
Tangri N et al. A predictive model for progression of chronic kidney disease to kidney failure. JAMA. DOI: 10.1001/jama.2011.451. PMID: 21482743. The 2011 footnote states that the albumin-to-creatinine hazard uses the natural log. The closed form was read from Table 7 of Kang MW, Tangri N, et al. An independent validation of the kidney failure risk equation in an Asian population. Sci Rep. DOI: 10.1038/s41598-020-69715-3. PMID: 32737361, which labels the row as the original 4-variable equation. Five-year risk percent = 100 × (1 − 0.9240^exp(−0.2201 × (age/10 − 7.036) + 0.2467 × (male − 0.5642) − 0.5567 × (eGFR/5 − 7.222) + 0.4510 × (ln ACR − 5.137))). Two-year risk uses baseline survival 0.9750 with the same linear predictor. Male is 1 and female is 0. ACR is mg/g. Whitlock RH et al. Validation of the Kidney Failure Risk Equation in Manitoba. Can J Kidney Health Dis. DOI: 10.1177/2054358117705372. PMID: 28491341. That validation tests a 5-year risk above 3% and above 10%. A result of 3% is not above 3%, and a result of 10% is not above 10%. (2011)
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