Hepatology · Gastroenterology
REACH-B Score for Hepatocellular Carcinoma calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–100 years
Points are printed only for ages 30 through 65 years: 0 for 30–34, then one more point for each older five-year band, through 6 points at 60–65. Outside that range the score is not calculated.
Allowed range: 0–2000 U/L
Under 15 U/L scores 0, 15 through 44 scores 1, and 45 or higher scores 2.
Allowed range: 0–1000000000000 copies/mL
Enter copies per mL. Below 10,000, including undetectable values under 300, scores 0. From 10,000 to just under 100,000 scores 3. From 100,000 to just under 1,000,000 scores 5. At or above 1,000,000 scores 4.
Result
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Clinical inputs
- Sex
- Age (years)Accepted range: 0 to 100
- Alanine aminotransferase (U/L)Accepted range: 0 to 2000
- HBeAg positive
- HBV DNA (copies/mL)Accepted range: 0 to 1000000000000
Primary source
Yang HI et al. Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Lancet Oncol. DOI: 10.1016/S1470-2045(11)70077-8. PMID: 21497551. Table 2 assigns 2 points for male sex; 0 through 6 points for ages 30–34, 35–39, 40–44, 45–49, 50–54, 55–59, and 60–65; 0, 1, or 2 points for ALT <15, 15–44, or ≥45 U/L; 2 points for HBeAg positive; and 0, 0, 3, 5, or 4 points for HBV DNA <300, 300–9,999, 10,000–99,999, 100,000–999,999, or ≥10^6 copies/mL. Table 3 lists the 3-year, 5-year, and 10-year HCC risks for each score from 0 to 17. An age under 30 or over 65 has no age row. (2011)
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