Hepatology
Revised original score for autoimmune hepatitis calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–20 ratio
Ratio of the elevations above the upper limit of normal. Under 1.5 scores +2, 1.5 through 3.0 scores 0, and above 3 scores −2.
Allowed range: 0.2–6 × normal
Under 1 scores 0. From 1 up to but not including 1.5 scores +1. From 1.5 through 2 inclusive scores +2. Above 2 scores +3. The printed rows overlap at 1.5, so 1.5 and 2.0 stay in the +2 row.
Allowed range: 0–200 g/day
Under 25 g/day scores +2, 25 through 60 g/day scores 0, and above 60 g/day scores −2.
Result
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Clinical inputs
- Sex
- ALP to ALT or AST ratioAccepted range: 0 to 20
- Globulin or IgG times normal (× normal)Accepted range: 0.2 to 6
- ANA, SMA, or LKM-1 titer
- Child
- Antimitochondrial antibody present
- Viral hepatitis markers positive
- Hepatotoxic drug history
- Average alcohol (g/day)Accepted range: 0 to 200
- Interface hepatitis, +3
- Predominant lymphoplasmacytic infiltrate, +1
- Hepatic rosettes, +1
- Biliary changes, −3
- Other defined histologic changes, −3
- Other autoimmune disease in the patient or a first-degree relative, +2
- Other defined autoantibodies
- HLA DR3 or DR4
- Treatment response
Primary source
Alvarez F et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929-938. PMID: 10580593. Female +2. ALP:ALT or ALP:AST ratio of elevations above the upper limit of normal: under 1.5 scores +2, 1.5 through 3.0 scores 0, and above 3 scores -2. Serum globulins or IgG times normal: under 1 scores 0, 1 up to but not including 1.5 scores +1, 1.5 through 2 inclusive scores +2, and above 2 scores +3. The printed rows overlap at 1.5, so 1.5 and 2.0 are placed in the +2 row. ANA, SMA, or LKM-1: under 1:40 scores 0, 1:40 scores +1, 1:80 scores +2, and above 1:80 scores +3. In a child, a titer under 1:40 scores +1. AMA positive scores -4. Viral markers positive score -3 and negative score +3. Hepatotoxic drug history scores -4, and no such history scores +1. Alcohol under 25 g/day scores +2, 25 through 60 g/day scores 0, and above 60 g/day scores -2. Interface hepatitis +3, predominant lymphoplasmacytic infiltrate +1, and rosettes +1. If none of those three is present, score -5. Biliary changes -3 and other defined changes -3 may be added. Other autoimmune disease +2. Other defined autoantibodies +2, and HLA DR3 or DR4 +1, only when ANA, SMA, and LKM-1 are all under 1:40. Response not assessed scores 0, complete response +2, and relapse +3. Before treatment, above 15 is definite, 10 through 15 is probable, and under 10 is not. After treatment, above 17 is definite, 12 through 17 is probable, and under 12 is not. (1999)
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