Gastroenterology · Hepatology

R Factor for Liver Injury calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Alanine aminotransferase (ALT)

U/L

Allowed range: 1–5000 U/L

Upper limit of normal for ALT

U/L

Allowed range: 1–200 U/L

Alkaline phosphatase (ALP)

U/L

Allowed range: 1–3000 U/L

Upper limit of normal for ALP

U/L

Allowed range: 1–300 U/L

Result

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Clinical inputs

Alanine aminotransferase (ALT) (U/L)Accepted range: 1 to 5000
Upper limit of normal for ALT (U/L)Accepted range: 1 to 200
Alkaline phosphatase (ALP) (U/L)Accepted range: 1 to 3000
Upper limit of normal for ALP (U/L)Accepted range: 1 to 300

Primary source

Danan G, Benichou C. Causality assessment of adverse reactions to drugs—I. J Clin Epidemiol. PMID: 8229110. R = (ALT/ULN) / (ALP/ULN). R ≤2 is cholestatic, R ≥5 is hepatocellular, and values between those bounds are mixed. The same bounds are used in the ACG DILI guideline (Chalasani N et al. Am J Gastroenterol. PMID: 24935270). (1993)

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