Gastroenterology · Oncology
GALAD Model calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–120 years
Allowed range: 0.1–1000000 ng/mL
Entered in ng/mL and transformed with log base 10. The value must be above 0.
Allowed range: 0–100 %
Allowed range: 0.1–1000000 ng/mL
Entered in ng/mL and transformed with log base 10. AFP-L3 stays a percentage and is not logged.
Result
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Clinical inputs
- Age in yearsAccepted range: 0 to 120
- Sex in the GALAD equation
- Alpha-fetoprotein (ng/mL)Accepted range: 0.1 to 1000000
- AFP-L3 percentage (%)Accepted range: 0 to 100
- Des-gamma-carboxy prothrombin (ng/mL)Accepted range: 0.1 to 1000000
Primary source
Johnson PJ et al. The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers. Cancer Epidemiol Biomarkers Prev. DOI: 10.1158/1055-9965.EPI-13-0870. PMID: 24220911. Model 5 from the combined Birmingham and Newcastle data: Z = −10.08 + 0.09×age + 1.67×male sex + 2.34×log10(AFP) + 0.04×AFP-L3 + 1.33×log10(DCP). Male sex is 1 and female sex is 0. Probability = exp(Z) / (1 + exp(Z)). Table 4 operating points for model 5 are Z = −1.36, −0.63, and 0.88. No single diagnostic threshold is applied. (2014)
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