Gastroenterology

Rome IV Reflux Hypersensitivity calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Months since symptom onset

months

Allowed range: 0–240 months

The source requires symptoms over the last 3 months and onset at least 6 months earlier.

Months the criteria have been fulfilled

months

Allowed range: 0–24 months

The source requires symptoms over the last 3 months and onset at least 6 months earlier.

Days per week with the symptom

days/week

Allowed range: 0–7 days/week

No major esophageal motor disorderRetrosternal symptoms, including heartburn or chest painNormal endoscopy and no eosinophilic esophagitisReflux events trigger symptoms despite normal acid exposure

Result

3 fields remaining

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F. Functional esophageal disorders. Gastroenterology. DOI: 10.1053/j.gastro.2016.02.012. PMID: 27144625. Reflux hypersensitivity requires retrosternal symptoms including heartburn and chest pain, normal endoscopy and no evidence that eosinophilic esophagitis is the cause, no major esophageal motor disorder, and evidence that reflux events trigger symptoms despite normal acid exposure on pH or pH-impedance monitoring. Response to antisecretory therapy does not exclude the diagnosis. Criteria are fulfilled for the past 3 months, with onset at least 6 months earlier, at least twice a week. (2016)

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Clinical inputs

Months since symptom onsetAccepted range: 0 to 240
Months the criteria have been fulfilledAccepted range: 0 to 24
Days per week with the symptom (days/week)Accepted range: 0 to 7
No major esophageal motor disorder
Retrosternal symptoms, including heartburn or chest pain
Normal endoscopy and no eosinophilic esophagitis
Reflux events trigger symptoms despite normal acid exposure

Primary source

Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F. Functional esophageal disorders. Gastroenterology. DOI: 10.1053/j.gastro.2016.02.012. PMID: 27144625. Reflux hypersensitivity requires retrosternal symptoms including heartburn and chest pain, normal endoscopy and no evidence that eosinophilic esophagitis is the cause, no major esophageal motor disorder, and evidence that reflux events trigger symptoms despite normal acid exposure on pH or pH-impedance monitoring. Response to antisecretory therapy does not exclude the diagnosis. Criteria are fulfilled for the past 3 months, with onset at least 6 months earlier, at least twice a week. (2016)

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