Gastroenterology · Primary Care
Steatosis-Associated Fibrosis Estimator calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 18–100 years
Allowed range: 10–80 kg/m²
A body mass index above 40 kg per square meter is entered as 40.
Allowed range: 1–2000 U/L
Allowed range: 1–2000 U/L
Allowed range: 0.5–10 g/dL
Enter g/dL. The score uses the natural logarithm.
Allowed range: 1–1000 10⁹/L
Result
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Clinical inputs
- Age (years)Accepted range: 18 to 100
- Body mass index (kg/m²)Accepted range: 10 to 80
- Diabetes
- Aspartate aminotransferase (U/L)Accepted range: 1 to 2000
- Alanine aminotransferase (U/L)Accepted range: 1 to 2000
- Globulin (g/dL)Accepted range: 0.5 to 10
- Platelet count (10⁹/L)Accepted range: 1 to 1000
Primary source
Sripongpun P et al. The steatosis-associated fibrosis estimator (SAFE) score: a tool to detect low-risk NAFLD in primary care. Hepatology. DOI: 10.1002/hep.32545. PMID: 35477908. The printed score is 2.97×age + 5.99×BMI (BMI above 40 is set to 40) + 62.85×diabetes (0 if absent, 1 if present) + 154.85×ln(AST in U/L) − 58.23×ln(ALT in U/L) + 195.48×ln(globulin in g/dL) − 141.61×ln(platelets in 10⁹/L) − 75. Below 0 is low risk, 0 up to but not including 100 is indeterminate, and 100 or higher is high risk. (2023)
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