Hematology and Oncology · Pulmonary
Immune-Related Pneumonitis Grade calculator
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Clinical inputs
Result
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Clinical inputs
- Lung extent
- Symptoms
- Medical intervention indicated
- Limiting instrumental activities of daily living
- Limiting self-care activities of daily living
- Oxygen indicated
- Hospitalization required
- Life-threatening respiratory compromise
- Urgent intervention indicated, including intubation
Primary source
Brahmer JR et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. PMID: 29442540. Table 3.1. Definition: focal or diffuse inflammation of the lung parenchyma, typically identified on CT. Grade 1: asymptomatic, confined to one lobe or < 25% of lung parenchyma, clinical or diagnostic observations only. Grade 2: symptomatic, more than one lobe or 25%–50% of lung parenchyma, medical intervention indicated, limiting instrumental ADL. Grade 3: severe symptoms, hospitalization required, all lung lobes or > 50% of lung parenchyma, limiting self-care ADL, oxygen indicated. Grade 4: life-threatening respiratory compromise, urgent intervention indicated (intubation). When more than one printed finding is present, the higher grade is returned. Management text from the table is not used. (2018)
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