Hematology and Oncology · Gastroenterology
Immune-Related Colitis Grade calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0–40 stools/day
Extra stools per day above the patient's baseline. One to three is grade 1, four to six is grade 2, and seven or more is grade 3, unless a higher finding is present. Zero is not an increase.
Result
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Clinical inputs
- Stool increase over baseline (stools/day)Accepted range: 0 to 40
- Ostomy output compared with baseline
- Incontinence
- Hospitalization indicated
- Limiting self-care activities of daily living
- Life-threatening consequences
- Urgent intervention indicated
Primary source
Brahmer JR et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. PMID: 29442540. Table 2.1 grades colitis with the CTCAE diarrhea descriptions printed there. Grade 1: increase of fewer than four stools per day over baseline; mild increase in ostomy output compared with baseline. Grade 2: increase of four to six stools per day over baseline; moderate increase in ostomy output compared with baseline. Grade 3: increase of seven or more stools per day over baseline, incontinence, hospitalization indicated, severe increase in ostomy output compared with baseline, limiting self-care ADL. Grade 4: life-threatening consequences; urgent intervention indicated. An increase of zero stools does not meet the grade 1 increase. When more than one printed finding is present, the higher grade is returned. Management text from the table is not used. (2018)
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