Hepatology · ICU and Critical Care
CLIF-C ACLF Score calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Allowed range: 0.1–60 mg/dL
Allowed range: 0.1–20 mg/dL
Allowed range: 0.5–12 ratio
Allowed range: 30–180 mmHg
Allowed range: 18–110 years
Allowed range: 0.1–100 ×10⁹/L
Result
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Clinical inputs
- Serum bilirubin (mg/dL)Accepted range: 0.1 to 60
- Creatinine (mg/dL)Accepted range: 0.1 to 20
- Renal replacement therapy
- West Haven grade of encephalopathy
- Ventilated for encephalopathy
- INR (ratio)Accepted range: 0.5 to 12
- Mean arterial pressure (mmHg)Accepted range: 30 to 180
- Vasopressors in use
- Gas-exchange row
- Ventilated for respiratory failure
- Age (years)Accepted range: 18 to 110
- White-cell count (×10⁹/L)Accepted range: 0.1 to 100
Primary source
Jalan R et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. DOI: 10.1016/j.jhep.2014.06.012. PMID: 24950482. CLIF-C ACLF = 10 × [0.33 × CLIF-C OF + 0.04 × age + 0.63 × ln(WBC ×10⁹/L) − 2], trimmed to 0–100. Table 2 organ points are 1/2/3: bilirubin <6 / ≥6 and <12 / ≥12 mg/dL; creatinine <2 / ≥2 and <3.5 / ≥3.5 mg/dL or renal replacement; West Haven 0 / 1–2 / 3–4; INR <2 / ≥2 and <2.5 / ≥2.5; MAP ≥70 mmHg / MAP <70 / vasopressors; PaO2/FiO2 >300 or SpO2/FiO2 >357 / PaO2/FiO2 >200 and ≤300 or SpO2/FiO2 >214 and ≤357 / PaO2/FiO2 ≤200 or SpO2/FiO2 ≤214. Ventilation for encephalopathy scores brain 3. Other ventilation scores respiration 3. (2014)
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