Emergency Medicine · Toxicology

CroFab Vial Regimen calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Initial CROFAB vials

vials

Allowed range: 4–12 vials

Section 2.1 allows 4 to 12 vials for the starting dose. 12 vials is the printed starting maximum.

Initial control already achieved

Control means the leading edge has stopped, systemic symptoms have resolved, and coagulation is normal or moving toward normal.

One extra dose if control is absent

vials

Allowed range: 4–6 vials

The label says 4 to 6 vials, repeated until control. No count of repeats is printed, so only this one extra dose enters the result.

Body weight

Allowed range: 2.2–551.16 lb

Section 2.1 does not use weight. The 250 kg entry limit is not a label cap.

Result

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Primary source

Crotalidae polyvalent immune Fab (ovine), CROFAB, prescribing information, FDA. Section 2.1. The recommended initial dose is 4 to 6 vials. The starting dose may vary from a minimum of 4 vials to a maximum of 12 vials. If initial control is not achieved by the first dose, an additional dose of 4 to 6 vials should be administered repeatedly until initial control has been achieved. Once initial control has been achieved, additional 2-vial doses every 6 hours for up to 18 hours (3 doses) are recommended. The label does not print a maximum number of those repeat doses or a maximum course total, so repeats after the first extra dose are not added. When control is already achieved, the result is the initial vials plus 6 maintenance vials. When control is not achieved, the result is the initial vials plus one extra dose of 4 to 6 vials, and the 6 maintenance vials stay out of the result until control. Section 2.1 does not print a per-kilogram dose or a kilogram cap. The 250 kg entry limit is not a label cap, and weight does not change the vial count. The dose has to be verified against the local protocol. (2018)

Scope: Adult and pediatric patients with North American crotalid envenomation treated with CROFAB. This is the section 2.1 vial regimen for that product.

Last reviewed 2026-10-17

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Crotalidae polyvalent immune Fab (ovine), CROFAB, prescribing information, FDA. Section 2.1. The recommended initial dose is 4 to 6 vials. The starting dose may vary from a minimum of 4 vials to a maximum of 12 vials. If initial control is not achieved by the first dose, an additional dose of 4 to 6 vials should be administered repeatedly until initial control has been achieved. Once initial control has been achieved, additional 2-vial doses every 6 hours for up to 18 hours (3 doses) are recommended. The label does not print a maximum number of those repeat doses or a maximum course total, so repeats after the first extra dose are not added. When control is already achieved, the result is the initial vials plus 6 maintenance vials. When control is not achieved, the result is the initial vials plus one extra dose of 4 to 6 vials, and the 6 maintenance vials stay out of the result until control. Section 2.1 does not print a per-kilogram dose or a kilogram cap. The 250 kg entry limit is not a label cap, and weight does not change the vial count. The dose has to be verified against the local protocol. (2018)

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Clinical inputs

Initial CROFAB vialsAccepted range: 4 to 12
Initial control already achieved
One extra dose if control is absent (vials)Accepted range: 4 to 6
Body weight (kg)Accepted range: 1 to 250

Primary source

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