Emergency Medicine · Toxicology

Naloxone Continuous Infusion calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Bolus that reversed respiratory depression

Allowed range: 0.1–100 mg

The hourly infusion is two-thirds of this bolus. No infusion maximum is printed. The 100 mg entry limit is not a printed ceiling.

Body weight

Allowed range: 4.41–551.16 lb

The nomogram does not use weight and does not print a kilogram cap. The 250 kg entry limit is not a printed cap.

Result

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Primary source

Goldfrank L, Weisman RS, Errick JK, Lo MW. A dosing nomogram for continuous infusion intravenous naloxone. Ann Emerg Med. PMID: 3963538. A continuous infusion of two-thirds of the bolus dose that resulted in reversal, each hour, maintained plasma levels at or above the level 30 minutes after that bolus. The result is that hourly rate in mg/h. The paper does not print an infusion maximum or a kilogram cap, and the rate does not use weight. The 100 mg and 250 kg entry limits are not printed caps. Naloxone hydrochloride injection labeling states that if no response is observed after 10 mg, the diagnosis of opioid-induced toxicity should be questioned. That 10 mg figure is not an infusion maximum and does not change the hourly rate. The dose has to be verified against the local protocol. (1986)

Scope: Patients who have had a naloxone bolus that reversed opioid-related respiratory depression and who are starting the continuous infusion from that bolus.

Last reviewed 2026-10-17

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Goldfrank L, Weisman RS, Errick JK, Lo MW. A dosing nomogram for continuous infusion intravenous naloxone. Ann Emerg Med. PMID: 3963538. A continuous infusion of two-thirds of the bolus dose that resulted in reversal, each hour, maintained plasma levels at or above the level 30 minutes after that bolus. The result is that hourly rate in mg/h. The paper does not print an infusion maximum or a kilogram cap, and the rate does not use weight. The 100 mg and 250 kg entry limits are not printed caps. Naloxone hydrochloride injection labeling states that if no response is observed after 10 mg, the diagnosis of opioid-induced toxicity should be questioned. That 10 mg figure is not an infusion maximum and does not change the hourly rate. The dose has to be verified against the local protocol. (1986)

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Clinical inputs

Bolus that reversed respiratory depression (mg)Accepted range: 0.1 to 100
Body weight (kg)Accepted range: 2 to 250

Primary source

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