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Neurology · Psychiatry

NINCDS-ADRDA Criteria for Alzheimer's Disease calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

years

Allowed range: 0–120 years

Quick picks

Probable disease uses onset from 40 years through 90 years.

Cognitive areas involved
Other disease that could explain the dementia

Probable disease needs no systemic or brain disease that accounts for the dementia.

Result

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Clinical inputs

  • Age at onset (years)Accepted range: 0 to 120
  • Examination, instrument, and neuropsychology agree
  • Cognitive areas involved
  • Memory and other cognition worsen over time
  • Consciousness is not disturbed
  • Other disease that could explain the dementia
  • Sudden onset
  • Early hemiparesis, sensory loss, field cut, or incoordination
  • Seizures or gait disturbance at onset or very early
  • Onset, presentation, or course varies
  • One gradually progressive severe cognitive deficit
  • Biopsy or autopsy histopathology

Primary source

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group. Neurology. DOI: 10.1212/WNL.34.7.939. PMID: 6610841. Table 1. Probable disease needs dementia documented by examination and a cognitive instrument and confirmed by neuropsychological tests, deficits in two or more cognitive areas, progressive worsening of memory and other cognitive functions, no disturbance of consciousness, onset from age 40 through 90, and no systemic or brain disease that accounts for the dementia. Sudden onset, early focal findings (hemiparesis, sensory loss, visual-field loss, or incoordination), and seizures or gait disturbance at onset or very early make probable disease uncertain or unlikely. When those other probable elements are present and no disorder accounts for the dementia, that onset or early course is the Table 1 variation, so the class is possible. Possible disease is also a dementia syndrome without a sufficient other cause plus any other variation in onset, presentation, or course; or a second disorder that could cause dementia but is not considered the cause; or one gradually progressive severe cognitive deficit without another identifiable cause. A disorder that accounts for the dementia is not Alzheimer disease. Definite disease is the probable clinical criteria plus histopathology from biopsy or autopsy. Histopathology does not upgrade a pattern that the table keeps out of probable disease. (1984)

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