Oncology · Urology

MSKCC/Motzer Score for Metastatic RCC calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Karnofsky performance status below 80

Lactate dehydrogenase

U/L

Allowed range: 50–5000 U/L

Upper reference limit for lactate dehydrogenase

U/L

Allowed range: 50–500 U/L

One point when the result is above 1.5 times this upper limit. A ratio of exactly 1.5 does not score.

Hemoglobin below the laboratory lower reference limit

Corrected calcium

mg/dL

Allowed range: 6–18 mg/dL

One point when corrected calcium is above 10 mg/dL. Exactly 10 does not score. The paper corrects total calcium as total calcium minus 0.707 times (albumin minus 3.4), with calcium in mg/dL and albumin in g/dL.

Less than 1 year from diagnosis to first systemic therapy

Result

3 fields remaining

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Motzer RJ et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. DOI: 10.1200/JCO.2002.20.1.289. PMID: 11773181. One point each for Karnofsky performance status below 80, LDH above 1.5 times the upper limit of normal, hemoglobin below the lower limit of normal, corrected calcium above 10 mg/dL, and less than 1 year from diagnosis to interferon-alfa. Zero factors: median survival 30 months. One or two: 14 months. Three or more: 5 months. The paper's corrected calcium is total calcium minus 0.707 times (albumin minus 3.4). (2002)

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Clinical inputs

Karnofsky performance status below 80
Lactate dehydrogenase (U/L)Accepted range: 50 to 5000
Upper reference limit for lactate dehydrogenase (U/L)Accepted range: 50 to 500
Hemoglobin below the laboratory lower reference limit
Corrected calcium (mg/dL)Accepted range: 6 to 18
Less than 1 year from diagnosis to first systemic therapy

Primary source

Motzer RJ et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. DOI: 10.1200/JCO.2002.20.1.289. PMID: 11773181. One point each for Karnofsky performance status below 80, LDH above 1.5 times the upper limit of normal, hemoglobin below the lower limit of normal, corrected calcium above 10 mg/dL, and less than 1 year from diagnosis to interferon-alfa. Zero factors: median survival 30 months. One or two: 14 months. Three or more: 5 months. The paper's corrected calcium is total calcium minus 0.707 times (albumin minus 3.4). (2002)

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