Oncology · Neurology

GI-GPA calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Karnofsky performance status

Below 80 scores 0. Exactly 80 scores 1. 90 through 100 scores 2. A value above 80 and below 90 is not assigned.

Age in years

years

Allowed range: 18–120 years

60 years or older scores 0. Younger than 60 scores 0.5.

Extracranial metastases

Number of brain metastases

Result

3 fields remaining

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Primary source

Sperduto PW et al. Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases. Clin Transl Radiat Oncol. DOI: 10.1016/j.ctro.2019.06.007. PMID: 31341974. Karnofsky below 80 scores 0, exactly 80 scores 1, and 90–100 scores 2. Age 60 or older scores 0 and younger than 60 scores 0.5. Absent extracranial metastases score 0.5. One brain metastasis scores 1, two or three score 0.5, and more than three score 0. Groups are 0–1.0, 1.5–2.0, 2.5–3.0, and 3.5–4.0. Both printings give median survival of 3 and 17 months for the outer groups. The middle groups are printed as 7 and 11 months in the results text and 9 and 12 months in the Table 4 caption. (2019)

Scope: Adults with gastrointestinal cancer and brain metastases. A Karnofsky score above 80 and below 90 is not assigned a column.

Last reviewed 2026-10-16

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Sperduto PW et al. Survival and prognostic factors in patients with gastrointestinal cancers and brain metastases. Clin Transl Radiat Oncol. DOI: 10.1016/j.ctro.2019.06.007. PMID: 31341974. Karnofsky below 80 scores 0, exactly 80 scores 1, and 90–100 scores 2. Age 60 or older scores 0 and younger than 60 scores 0.5. Absent extracranial metastases score 0.5. One brain metastasis scores 1, two or three score 0.5, and more than three score 0. Groups are 0–1.0, 1.5–2.0, 2.5–3.0, and 3.5–4.0. Both printings give median survival of 3 and 17 months for the outer groups. The middle groups are printed as 7 and 11 months in the results text and 9 and 12 months in the Table 4 caption. (2019)

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Clinical inputs

Karnofsky performance status
Age in yearsAccepted range: 18 to 120
Extracranial metastases
Number of brain metastases

Primary source

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