Obstetrics · Haematology

RhoGAM Dose for Rh-Positive Red Cell Exposure calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Rh-positive red cell volume

Allowed range: 0.1–5000 mL

Enter red-cell milliliters, the unit in the label. One 300 µg syringe covers 15 mL. Above that, use 20 µg per mL and round up to a whole syringe. No maximum syringe count is printed.

Result

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Primary source

Kedrion Biopharma. RhoGAM Ultra-Filtered PLUS [Rho(D) Immune Globulin (Human)] prescribing information, revised 2025. Each prefilled syringe contains 300 µg (1500 IU) and suppresses immunization from up to 15 mL of Rh-positive red blood cells. For exposure above 15 mL, administer 20 µg per mL of Rh-positive red blood cells, rounding up to the next whole syringe. The same 20 µg per mL rule yields one 300 µg syringe at 15 mL and at any smaller positive exposure covered by one syringe. The label does not print a maximum number of syringes. Give the total dose within 72 hours of exposure. Intramuscular use. Do not inject the newborn. (2025)

Scope: Rh-negative patients with a measured exposure to Rh-positive red blood cells. The input is red-cell volume in mL, which is the unit in the label.

Last reviewed 2026-10-17

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Professional use only

For qualified clinicians. Independently verify inputs, calculations, source guidance, and applicability before any clinical action. This calculator does not replace clinical judgment.

Source: Kedrion Biopharma. RhoGAM Ultra-Filtered PLUS [Rho(D) Immune Globulin (Human)] prescribing information, revised 2025. Each prefilled syringe contains 300 µg (1500 IU) and suppresses immunization from up to 15 mL of Rh-positive red blood cells. For exposure above 15 mL, administer 20 µg per mL of Rh-positive red blood cells, rounding up to the next whole syringe. The same 20 µg per mL rule yields one 300 µg syringe at 15 mL and at any smaller positive exposure covered by one syringe. The label does not print a maximum number of syringes. Give the total dose within 72 hours of exposure. Intramuscular use. Do not inject the newborn. (2025)

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Clinical inputs

Rh-positive red cell volume (mL)Accepted range: 0.1 to 5000

Primary source

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