Framingham Risk Score for Hard Coronary Heart Disease calculator

Clinical inputs

• Sex
• Age (years)Accepted range: 30 to 79
• Total cholesterol (mg/dL)Accepted range: 100 to 400
• HDL cholesterol (mg/dL)Accepted range: 20 to 100
• Systolic blood pressure (mmHg)Accepted range: 90 to 200
• On treatment for hypertension
• Current smoker

Primary source

Framingham Heart Study. Hard Coronary Heart Disease (10-year risk), the function adopted by the National Cholesterol Education Program Adult Treatment Panel III (Executive Summary of the Third Report of the NCEP Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, JAMA 2001). Outcome: myocardial infarction or coronary death; ages 30 to 79 free of CHD, intermittent claudication and diabetes. Cox coefficients (mean) for men: ln age 52.009610 (3.8926095), ln total cholesterol 20.014077 (5.3441475), ln HDL -0.905964 (3.7731132), ln SBP 1.305784 (4.8618212), treatment for hypertension (SBP > 120) 0.241549 (0.1180474), current smoker 12.096316 (0.3356020), ln age x ln total cholesterol -4.605038 (20.8111562), ln age x smoker -2.843670 (1.2890301, age capped at 70), ln age x ln age -2.933230 (15.2144965); baseline survival 0.940200. Women: ln age 31.764001 (3.9213204), ln total cholesterol 22.465206 (5.3628984), ln HDL -1.187731 (4.0146369), ln SBP 2.552905 (4.8376494), treatment 0.420251 (0.1428020), smoker 13.075430 (0.3236202), ln age x ln total cholesterol -5.060998 (21.0557746), ln age x smoker -2.996945 (1.2519882, age capped at 78); baseline survival 0.987670. Risk = 1 - S0^exp(sum of coefficient x value minus sum of coefficient x mean). Bands are the ATP III 10-year risk groups printed in the NHLBI ATP III At-A-Glance Quick Desk Reference: below 10%, 10-20%, and above 20% (CHD risk equivalent). (2001)