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Nephrology · Internal Medicine

Transtubular Chloride Gradient (TTCG) calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Result

Complete all required inputs to calculate the score.

Formula inputs

  • Urine chloride (mmol/L)Accepted range: 1 to 200
  • Serum chloride (mmol/L)Accepted range: 70 to 140
  • Urine osmolality (mOsm/kg)Accepted range: 50 to 1200
  • Serum osmolality (mOsm/kg)Accepted range: 250 to 350

Primary source

Carlotti AP et al. Transtubular chloride gradient: a useful parameter for evaluating renal chloride handling. J Pediatr. DOI: 10.1016/S0022-3476(05)80012-3. PMID: 7701160. Scope: transtubular chloride gradient = (urine chloride Ă— serum osmolality) / (serum chloride Ă— urine osmolality) when urine is at least iso-osmolar to plasma. (1995)

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