Nephrology · Internal Medicine
Transtubular Chloride Gradient (TTCG) calculator
Enter the published formula inputs below to calculate and interpret this score.
Clinical inputs
Result
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Formula inputs
- Urine chloride (mmol/L)Accepted range: 1 to 200
- Serum chloride (mmol/L)Accepted range: 70 to 140
- Urine osmolality (mOsm/kg)Accepted range: 50 to 1200
- Serum osmolality (mOsm/kg)Accepted range: 250 to 350
Primary source
Carlotti AP et al. Transtubular chloride gradient: a useful parameter for evaluating renal chloride handling. J Pediatr. DOI: 10.1016/S0022-3476(05)80012-3. PMID: 7701160. Scope: transtubular chloride gradient = (urine chloride × serum osmolality) / (serum chloride × urine osmolality) when urine is at least iso-osmolar to plasma. (1995)
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