Haematology · Oncology

2015 Revised International Staging System (R-ISS) for Multiple Myeloma calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

International Staging System (ISS) stage

ISS I: serum β₂-microglobulin <3.5 mg/L and albumin ≥3.5 g/dL. ISS III: serum β₂-microglobulin ≥5.5 mg/L. ISS II: neither I nor III. High-risk cytogenetics are del(17p), t(4;14), or t(14;16).

High-risk cytogenetics

Serum LDH above the laboratory ULN

Result

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Clinical inputs

International Staging System (ISS) stage
High-risk cytogenetics
Serum LDH above the laboratory ULN

Primary source

Palumbo A et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J Clin Oncol. DOI: 10.1200/JCO.2015.61.2267. PMID: 26240224 (2015)

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