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Dermatology · Allergy and Immunology

RegiSCAR Score for DRESS calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Fever ≥38.5°C
Enlarged lymph nodes >1 cm at two or more anatomical sites
Eosinophilia

Use absolute eosinophil count unless total leukocytes are <4 ×10⁹/L; in that setting use eosinophil percentage thresholds of 10–19.9% and ≥20%.

Atypical lymphocytes
Skin rash involving >50% of body surface area
Rash suggesting DRESS with at least two characteristic features
Skin biopsy suggesting DRESS
Internal-organ involvement
Clinical resolution taking ≥15 days
At least three specified alternative-cause investigations negative

Result

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Clinical inputs

  • Fever ≥38.5°C
  • Enlarged lymph nodes >1 cm at two or more anatomical sites
  • Eosinophilia
  • Atypical lymphocytes
  • Skin rash involving >50% of body surface area
  • Rash suggesting DRESS with at least two characteristic features
  • Skin biopsy suggesting DRESS
  • Internal-organ involvement
  • Clinical resolution taking ≥15 days
  • At least three specified alternative-cause investigations negative

Primary source

Kardaun SH et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. DOI: 10.1111/j.1365-2133.2006.07704.x. PMID: 17300272. Scope: RegiSCAR validation scoring for hospitalized suspected drug hypersensitivity cases; yes/no/unknown states retain the published item-specific values. (2007)

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