Internal Medicine · Emergency Medicine · Nephrology

Anion Gap Delta (ΔAG) calculator

Enter the published formula inputs below to calculate and interpret this score.

Clinical inputs

Serum sodium (mmol/L)

Serum chloride (mmol/L)

Serum bicarbonate (mmol/L)

Reference anion gap (mmol/L)

Reference anion gap used for delta calculation; 12 mEq/L is the conventional normal value.

Result

Complete all required inputs to calculate the score.

Formula inputs

Serum sodium (mmol/L)Accepted range: 100 to 180
Serum chloride (mmol/L)Accepted range: 70 to 140
Serum bicarbonate (mmol/L)Accepted range: 1 to 45
Reference anion gap (mmol/L)Accepted range: 6 to 16

Primary source

Wrenn K et al. The delta (delta) gap: an approach to the bedside diagnosis of metabolic acidosis. Ann Emerg Med. DOI: 10.1016/S0196-0644(90)80286-3. PMID: 2300381. Scope: delta anion gap = measured anion gap − reference anion gap, where anion gap = sodium − (chloride + bicarbonate). (1990)

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